The evaluation of drug-testing device for ketamine and its metabolites in body fluid

• Main Authors: Tung-Jun Wu, 吳東潤
• Other Authors: Yung-Fou Chen
• Format: Others
• Language: zh-TW
• Published: 1040
• Online Access: http://ndltd.ncl.edu.tw/handle/12429930262335397188

碩士 === 中央警察大學 === 鑑識科學研究所 === 103 === This study was done to test the interference for newly developed drug screening test drive and investigate Ketamine threshold between saliva and other body fluid, providing future relevant law enforcement officers when used as a reference. In this study, Gas Chromatograph Mass Spectrometer (GCMS) and liquid tandem quadrupole time of flight mass spectrometry (LC-Q-TOF) for the test equipment, GCMS test Ketamine (K) and Norketamine (NK) of urine and saliva of the method of linear range of the calibration curve 25-1000ng / mL, Dehydronorketamine (DHNK) method linear range of the calibration curve 50-1000ng / mL, the linear correlation coefficient of 0.99 are above detection limit and quantitation limit K and NK are is 25ng/mL, DHNK is 50ng/mL; in the LC-Q-TOF , K, NK and DHNK of urine and saliva method linear range of the calibration curve 5-1000ng / mL, the linear correlation coefficient of 0.99 are above detection limit and quantification limit are 5ng / mL, saliva and urine of liquid extraction recoveries above 88%.In the real sample results ,Prevalence Regression to the police sample, Ketamine threshold of saliva is about 51.31 ng / mL, K + NK threshold of saliva is about 32.92 ng / mL; Prevalence Regression to sanatorium specimen , Ketamine threshold of saliva is about 14.61 ng / mL, K + NK threshold of saliva is 20.26 ng / mL. Saliva threshold value of this study hoping to provide future regulations refer to the proposal to establish a threshold value of drug driving.