Preparation and characterization of oral disintegrable pellets

• Main Authors: Chun- Hsien Li, 李俊賢
• Other Authors: Heng-Hong Lin
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/33420150897749644148

碩士 === 嘉南藥理大學 === 藥學系 === 103 === During the production of orally ingested pellets, we can adjust the formula to achieve the dissolution profile we desire. The study is to create pellets that will dissolve when taken orally but will not dissolve during the preparing process. In comparison to previous pellets prepared by other methods, as sodium alginate does not easily break down, the addition of disintegrating agents may be allowed the pellet to dissolve more easily. The following disintegration agents such as Primogel, kollidone, Avicel will be used in the research. In our preparing process, we combine sodium alginate and the disintegrating agents in the proper mixture ratio. The addition of alcohol also plays an important role in the mixture. And then the mixture would be slowly dropped into a calcium chloride solution to prepare pellets. The pellet was dried in oven and was investigated the particle size changed and physical-chemical properties by texture analyzer and dissolution study. Compare the experimental statuses of ten groups respectively, we compare the dimension of freshly prepared drop pills and rounded grains with drop pills after drying, and compare the dimension of drop pills and rounded grains after drying with rounded grains after soaking for 5 minutes and for 24 hours respectively and make curve diagram to observe its dimension change, difference and required time.Finally, we can find that drop pills and rounded grains made by the formula for group N02, observed after drying and overlaying water, their situations show that the dimension change of drop pills in a short time is larger and meet the principles of required time of disintegration of drop pills is short and rapid variation. The results show that the particle size of the pellet which was combined with disintegrants was larger than that without disintegrants through dry process. To reconstitute dry pellets by water, has significant swelling effect on pellets. The above results will be helpful to possible development of the other disintegrable pellet controlled delivery systems