Biocompatibility and Drug Release Behavior of Sodium Alginate /Pectin Hydrogel Beads Containing Curcumin

• Main Authors: CHANG,CHIA-JUNG, 張家榕
• Other Authors: Jao, Win Chun
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/63622648031436370781

碩士 === 中華科技大學 === 健康科技研究所 === 103 === Curcumin, a hydrophobic phenolic compound, has been shown to possess several pharmacological activities such as antioxidant, anti-inflammatory, antiviral, antifungal and anti-tumorigenic activities. In this study, the mixture of sodium alginate (ALG) and pectin (PEC) was crosslinked with Ca2+ to form pH-sensitive hydrogel beads. The swelling and pH-sensitive properties of the sodium alginate/pectin (ALG/PEC) hydrogel beads were tested different pH environments. The drug release behaviors of the loaded curcumin ALG/PEC hydrogel beads were investigated in simulated intestinal fluid (SIF) and simulated colonic fluid (SCF). In addition, DPPH radical-scavenging and total phenolic content assays were employed to measure antioxidant activities of the curcumin-loaded ALG/PEC hydrogel beads. Finally, the cytotoxic effects of the curcumin-loaded ALG/PEC hydrogel beads on L929 mouse fibroblasts were evaluated by MTT assay. The results suggested that the curcumin-loaded ALG/PEC hydrogel beads may be a potential carrier for oral administration of site-specific drugs.