Biocompatibility and Drug Release Behavior of Sodium Alginate /Pectin Hydrogel Beads Containing Curcumin
碩士 === 中華科技大學 === 健康科技研究所 === 103 === Curcumin, a hydrophobic phenolic compound, has been shown to possess several pharmacological activities such as antioxidant, anti-inflammatory, antiviral, antifungal and anti-tumorigenic activities. In this study, the mixture of sodium alginate (ALG) and pectin...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2015
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| Online Access: | http://ndltd.ncl.edu.tw/handle/63622648031436370781 |
| Summary: | 碩士 === 中華科技大學 === 健康科技研究所 === 103 === Curcumin, a hydrophobic phenolic compound, has been shown to possess several pharmacological activities such as antioxidant, anti-inflammatory, antiviral, antifungal and anti-tumorigenic activities. In this study, the mixture of sodium alginate (ALG) and pectin (PEC) was crosslinked with Ca2+ to form pH-sensitive hydrogel beads. The swelling and pH-sensitive properties of the sodium alginate/pectin (ALG/PEC) hydrogel beads were tested different pH environments. The drug release behaviors of the loaded curcumin ALG/PEC hydrogel beads were investigated in simulated intestinal fluid (SIF) and simulated colonic fluid (SCF). In addition, DPPH radical-scavenging and total phenolic content assays were employed to measure antioxidant activities of the curcumin-loaded ALG/PEC hydrogel beads. Finally, the cytotoxic effects of the curcumin-loaded ALG/PEC hydrogel beads on L929 mouse fibroblasts were evaluated by MTT assay. The results suggested that the curcumin-loaded ALG/PEC hydrogel beads may be a potential carrier for oral administration of site-specific drugs.
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