The Transplantation of Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord on Treatment for Spinocerebellar Ataxia Type 1 Mouse

The Transplantation of Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord on Treatment for Spinocerebellar Ataxia Type 1 Mouse

碩士 === 國立陽明大學 === 解剖學及細胞生物學研究所 === 102 === In the present study, human umbilical mesenchymal stem cells (HUMSCs) were transplanted into the cerebellum of spinocerebellar ataxia type 1 (SCA1) transgenic mice to investigate whether they could ameliorate the shrinkage of cerebellum and loss of cerebe...

Full description

Bibliographic Details
Main Authors: Wan-Jhen Huang, 黃婉禎
Other Authors: Yu-Show Fu
Format: Others
Language:zh-TW
Published: 2014
Online Access:http://ndltd.ncl.edu.tw/handle/34a4mu
id ndltd-TW-102YM005391002
record_format oai_dc
spelling ndltd-TW-102YM0053910022019-05-15T21:32:33Z http://ndltd.ncl.edu.tw/handle/34a4mu The Transplantation of Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord on Treatment for Spinocerebellar Ataxia Type 1 Mouse 移植人類臍帶間質幹細胞治療小鼠的第一型脊髓小腦共濟失調症 Wan-Jhen Huang 黃婉禎 碩士 國立陽明大學 解剖學及細胞生物學研究所 102 In the present study, human umbilical mesenchymal stem cells (HUMSCs) were transplanted into the cerebellum of spinocerebellar ataxia type 1 (SCA1) transgenic mice to investigate whether they could ameliorate the shrinkage of cerebellum and loss of cerebellar function. HUMSC transplants effectively protected cerebellum from atrophy, prevented Purkinje cell death, and ameliorated motor performance by increasing muscular response after stimuli. Our findings provide a new therapeutic direction for clinical treatment of SCA1. Yu-Show Fu 傅毓秀 2014 學位論文 ; thesis 135 zh-TW
collection NDLTD
language zh-TW
format Others
sources NDLTD
description 碩士 === 國立陽明大學 === 解剖學及細胞生物學研究所 === 102 === In the present study, human umbilical mesenchymal stem cells (HUMSCs) were transplanted into the cerebellum of spinocerebellar ataxia type 1 (SCA1) transgenic mice to investigate whether they could ameliorate the shrinkage of cerebellum and loss of cerebellar function. HUMSC transplants effectively protected cerebellum from atrophy, prevented Purkinje cell death, and ameliorated motor performance by increasing muscular response after stimuli. Our findings provide a new therapeutic direction for clinical treatment of SCA1.
author2 Yu-Show Fu
author_facet Yu-Show Fu
Wan-Jhen Huang
黃婉禎
author Wan-Jhen Huang
黃婉禎
spellingShingle Wan-Jhen Huang
黃婉禎
The Transplantation of Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord on Treatment for Spinocerebellar Ataxia Type 1 Mouse
author_sort Wan-Jhen Huang
title The Transplantation of Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord on Treatment for Spinocerebellar Ataxia Type 1 Mouse
title_short The Transplantation of Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord on Treatment for Spinocerebellar Ataxia Type 1 Mouse
title_full The Transplantation of Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord on Treatment for Spinocerebellar Ataxia Type 1 Mouse
title_fullStr The Transplantation of Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord on Treatment for Spinocerebellar Ataxia Type 1 Mouse
title_full_unstemmed The Transplantation of Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord on Treatment for Spinocerebellar Ataxia Type 1 Mouse
title_sort transplantation of mesenchymal stem cells in wharton's jelly of the human umbilical cord on treatment for spinocerebellar ataxia type 1 mouse
publishDate 2014
url http://ndltd.ncl.edu.tw/handle/34a4mu
work_keys_str_mv AT wanjhenhuang thetransplantationofmesenchymalstemcellsinwhartonsjellyofthehumanumbilicalcordontreatmentforspinocerebellarataxiatype1mouse
AT huángwǎnzhēn thetransplantationofmesenchymalstemcellsinwhartonsjellyofthehumanumbilicalcordontreatmentforspinocerebellarataxiatype1mouse
AT wanjhenhuang yízhírénlèiqídàijiānzhìgànxìbāozhìliáoxiǎoshǔdedìyīxíngjísuǐxiǎonǎogòngjìshīdiàozhèng
AT huángwǎnzhēn yízhírénlèiqídàijiānzhìgànxìbāozhìliáoxiǎoshǔdedìyīxíngjísuǐxiǎonǎogòngjìshīdiàozhèng
AT wanjhenhuang transplantationofmesenchymalstemcellsinwhartonsjellyofthehumanumbilicalcordontreatmentforspinocerebellarataxiatype1mouse
AT huángwǎnzhēn transplantationofmesenchymalstemcellsinwhartonsjellyofthehumanumbilicalcordontreatmentforspinocerebellarataxiatype1mouse
_version_ 1719115940368482304

Similar Items