Feasibility of 3D printable calcium sulfate bio-ink for bone graft substitute applications

• Main Authors: Ting-Yueh Chen, 陳鼎岳
• Other Authors: 黃茂栓
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/7vb8e3

碩士 === 臺北醫學大學 === 醫療器材產業碩士專班 === 102 === Calcium sulfate has been used as one of the absorbable bone substitute materials and is highly biocompatible and osteoconductive. Calcium sulfate based bone grafting material has short setting, and as a result could be used for additive manufacturing technology, such as 3D printing. Calcium sulfate bone cement replacement can be exploited into bio-ink and used for customized bone graft substitute through 3D printing. The proposed research is to be prepared calcium sulfate biological ink and explore the feasibility of alternative bone graft. A set of synthesis and processing techniques based will be developed to prepare the calcium sulfate bio-ink. The prepared bio-ink will be characterized by using material characterization tools including optical microscopy (OM), scanning electron microscopy (SEM), transmission electron microscopy (TEM). Hardness and mechanical properties are determined for further investigation of 3D printing process. Additionally, in order to confirm the biocompatibility for bone graft application, a series of cell experiments will also conducted. These features can be useful in understanding the relationship between the microstructure, physical and mechanical properties of the calcium sulfate bio-ink. The analytical results indicated that the calcium sulfate is a potential 3D printing material that can be applied in biomedical applications.