| Summary: | 碩士 === 臺北醫學大學 === 藥學系(碩博士班) === 102 === The aim of this study was to prepare and characterize a swellable and bioadhesive gastroretentive drug delivery system (GRDDS) based on the complex hydrogel formed between chitosan and polyvinyl pyrrolidone (PVP) via cross-linking of charge interaction. Such a novel GRDDS system could not only sustain release of drug but also increase the residence time of the drug in stomach by two retentive mechanisms of swelling and bioadhesion. Due to these superiorities, those active ingredients (alendronate sodium as the model drug) with the absorption window located in the upper GI tract can be released continuously and sustainably from the upstream of stomach and passed through the absorption region in the upper GI tract resulting in the enhancement of the bioavailability. Besides, the mucosa adhesion of Chitosan and higher viscosity and rigidity of the complex hydrogel potentially minimizes the local irritation of active ingredient (alendronate sodium) by forming a protection layer on the mucosa membrane of stomach and by slower releasing active ingredients. "Osteoporosis" is one of the major diseases affecting the health o f the elderly, and currently the most commonly used treatment of osteoporosis is bisphosphonates. However, the biggest drawbacks of this kind of medicines are low bioavailability and topical stimulation on upper gastrointestinal (GI) mucosa. It was selected as the model drug in this study.
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