The study of polymeric micelles'' stability and transdermal penetration by fluorescence dye

• Main Authors: Hui-Ling Hsu, 徐慧玲
• Other Authors: 廖嘉鴻
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/77ras8

碩士 === 臺北醫學大學 === 藥學系(碩博士班) === 102 === The study used two fluorescence dyes’ Fluorescence resonance energy transfer (FRET) to evaluate the stability of polymeric micelles by timing, environment, and mechanical shake.Moreover, we also use FRET to evaluate pros and cons of different polymers’ energy transfer. In vitro, we formulated polymeric micelles and two fluorescence dyes and observed the transdermal permeation by Franz Diffusion Cell System. The results found that polymeric micelles and two fluorescence dyes’ ratio can sustain stable during 0～8 hours. Polymeric micelles and two fluorescence dyes’ ratio we affected under concentration of different dilutions, and the ratio could maintain stable mechanical under shaking. However, the different polymeric micelles’ FRET was different under different concentration fluorescence dyes.During 0～24 hours of Franz Diffusion Cell System’s experiment, it were found that two fluorescence dyes’ could transdermal penetration.