| Summary: | 碩士 === 淡江大學 === 化學學系碩士班 === 102 === 1, 8 - Naphthalimides derivatives have strong fluorescence characters and their synthesis have been widely studied. They have been commonly used as fluorescent probes, anticancer agents, fluorescent cellular imaging agents and fluorescent dyes. They possess planar scaffold and stable conjugated system to lead to more photochemical stability, large Stokes shift and multiple fluorescence properties.
Because 1, 8 - Naphthalimides derivatives have various application, therefore we want to explane a facile synthesis of derivatives to expect higher fluorescence efficiency.
The first part is synthesis of nitrogen 1, 8 - Naphthalimides derivatives. These compounds can be complex with metal ion through lone pairs to lead to chelating structure. The fluorescence properties would be changed that can be used the metal ion probe in the future. Furthermore we can test its structure – activity relationship (SAR) studies as anticancer agents.
The second part is synthesis of extended 1, 8 - Naphthalimides planarity derivatives. Arylation of azoles is mediated by Pd – Cu system. We can change the resulting adducts from weaker blue - violet fluorescence to stronger conjugated system with yellow-green fluorescence. It can be novel fluorescent labeling agents or fluorescent dyes.
Low concentrations, these different functional 1, 8 - Naphthalimides derivative to produce intense fluorescence properties. They can be more widely used in various aspects.
|
|---|
