Catalyst-Free Synthesis of 1,5-Benzodiazepines by Cyclocondensation of β,γ-Unsaturated Ketones with o-Phenylenediamine

碩士 === 淡江大學 === 化學學系碩士班 === 102 === The benzodiazepines have attracted much attentions as pharmacophoric scaffold of heterocycles with a wide range of biological applications. These compounds are served as potentially biological compound with antianxiety, anti-depress, anti-inflammatory, anti-viral,...

Full description

Bibliographic Details
Main Authors:	Yen-Ruei Zhu, 朱彥睿
Other Authors:	李世元
Format:	Others
Language:	zh-TW
Published:	2014
Online Access:	http://ndltd.ncl.edu.tw/handle/5a793c

id	ndltd-TW-102TKU05065072
record_format	oai_dc
spelling	ndltd-TW-102TKU050650722019-05-15T21:42:45Z http://ndltd.ncl.edu.tw/handle/5a793c Catalyst-Free Synthesis of 1,5-Benzodiazepines by Cyclocondensation of β,γ-Unsaturated Ketones with o-Phenylenediamine 無催化劑條件下以β,γ-不飽和酮與鄰苯二胺環化合成1,5-苯二氮䓬類 Yen-Ruei Zhu 朱彥睿碩士淡江大學化學學系碩士班 102 The benzodiazepines have attracted much attentions as pharmacophoric scaffold of heterocycles with a wide range of biological applications. These compounds are served as potentially biological compound with antianxiety, anti-depress, anti-inflammatory, anti-viral, anti-HIVand anti-microbial activities.Many synthetic methods for benzodiazepines have been reported,and mostly with the introduction of catalyst. We developed a novel catalyst-free method synthetic of 1,5-benzodiazepines which was obtained under sonochemical Barbier-type reaction conditions. A reation mixture of activated magnesium powder, allyl bromide and aldehyde was sonicated to genterate allyl alcohol, followed by treatment of PCC to oxidize the allyl alcohol to allyl ketone.The cyclocondensation reaction of allyl ketone with o-phenylenediamine can produce 1,5-Benzodiazepines. 李世元 2014 學位論文 ; thesis 89 zh-TW
collection	NDLTD
language	zh-TW
format	Others
sources	NDLTD
description	碩士 === 淡江大學 === 化學學系碩士班 === 102 === The benzodiazepines have attracted much attentions as pharmacophoric scaffold of heterocycles with a wide range of biological applications. These compounds are served as potentially biological compound with antianxiety, anti-depress, anti-inflammatory, anti-viral, anti-HIVand anti-microbial activities.Many synthetic methods for benzodiazepines have been reported,and mostly with the introduction of catalyst. We developed a novel catalyst-free method synthetic of 1,5-benzodiazepines which was obtained under sonochemical Barbier-type reaction conditions. A reation mixture of activated magnesium powder, allyl bromide and aldehyde was sonicated to genterate allyl alcohol, followed by treatment of PCC to oxidize the allyl alcohol to allyl ketone.The cyclocondensation reaction of allyl ketone with o-phenylenediamine can produce 1,5-Benzodiazepines.
author2	李世元
author_facet	李世元 Yen-Ruei Zhu 朱彥睿
author	Yen-Ruei Zhu 朱彥睿
spellingShingle	Yen-Ruei Zhu 朱彥睿 Catalyst-Free Synthesis of 1,5-Benzodiazepines by Cyclocondensation of β,γ-Unsaturated Ketones with o-Phenylenediamine
author_sort	Yen-Ruei Zhu
title	Catalyst-Free Synthesis of 1,5-Benzodiazepines by Cyclocondensation of β,γ-Unsaturated Ketones with o-Phenylenediamine
title_short	Catalyst-Free Synthesis of 1,5-Benzodiazepines by Cyclocondensation of β,γ-Unsaturated Ketones with o-Phenylenediamine
title_full	Catalyst-Free Synthesis of 1,5-Benzodiazepines by Cyclocondensation of β,γ-Unsaturated Ketones with o-Phenylenediamine
title_fullStr	Catalyst-Free Synthesis of 1,5-Benzodiazepines by Cyclocondensation of β,γ-Unsaturated Ketones with o-Phenylenediamine
title_full_unstemmed	Catalyst-Free Synthesis of 1,5-Benzodiazepines by Cyclocondensation of β,γ-Unsaturated Ketones with o-Phenylenediamine
title_sort	catalyst-free synthesis of 1,5-benzodiazepines by cyclocondensation of β,γ-unsaturated ketones with o-phenylenediamine
publishDate	2014
url	http://ndltd.ncl.edu.tw/handle/5a793c
work_keys_str_mv	AT yenrueizhu catalystfreesynthesisof15benzodiazepinesbycyclocondensationofbgunsaturatedketoneswithophenylenediamine AT zhūyànruì catalystfreesynthesisof15benzodiazepinesbycyclocondensationofbgunsaturatedketoneswithophenylenediamine AT yenrueizhu wúcuīhuàjìtiáojiànxiàyǐbgbùbǎohétóngyǔlínběnèrànhuánhuàhéchéng15běnèrdànzhuólèi AT zhūyànruì wúcuīhuàjìtiáojiànxiàyǐbgbùbǎohétóngyǔlínběnèrànhuánhuàhéchéng15běnèrdànzhuólèi
_version_	1719118514136023040

Catalyst-Free Synthesis of 1,5-Benzodiazepines by Cyclocondensation of β,γ-Unsaturated Ketones with o-Phenylenediamine

Similar Items