Design and analysis for a drug release device - for instance in polymer solvent

• Main Authors: Jheng-Fong You, 游政峰
• Other Authors: Chih-Cheng Lu
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/qmcy82

碩士 === 國立臺北科技大學 === 機電整合研究所 === 102 === In this study, the use of micro mechanical structure for storage and drug release, intended to replace traditional medical activity, use syringes to drug delivery approach. Choose a Certified titanium explants, and using Pro / Engineer designs can Correspondingly institutional structure of titanium metal implant, this mechanism has a liquid medicine storage chamber, with selectable scale displacement or pressure type two mechanical pusher, and the use of polymer - chitosan solution was prepared with different concentrations of the release experiment. Weight percentage of displacement can be released from 0.283% to 1.095%, another weight percentage Pressure released from 0.021% to 0.885%, so both storage and accurate drug delivery function, can be used to facilitate drug delivery in the future of the human body. In addition, in the piezoelectric propulsion, flow field using COMSOL Multiphysics simulation software, perform structural analysis of piezoelectric fluid coupling, the results found that the zinc oxide piezoelectric, after converse piezoelectric effect the average outlet velocity was 3.31*10-6 mm/s, actual available piezoelectric for experiment, the results showed an increase of 50% polymer in the piezoelectric more than another without piezoelectric after 80 minutes, the two different drugs to release, and applications can be made on the release of drugs for different needs, the design combined agency dental implants and artificial, to be implanted in the mouth above the maxillary position, because at contain more connective tissue and blood, can be beneficial to take the set and the drug release mechanism.