| Summary: | 碩士 === 國立臺北科技大學 === 材料科學與工程研究所 === 102 === In this study, we prepared zinc-doped hydroxyapatite by the co-precipitation method, the purpose is to make artificial bone material has ability of antibacterial. The co-precipitation method prepared hydroxyapatite with add different concentrations of zinc chloride. Detected the weight loss by TGA to determine the sintering temperature of the pyrolysis temperature.Detected by XRD, the experimental results show that after sintering, it has some new phases generated of ZnO and CaZn2 (PO4)2, and the strength of new phases will high over than hydroxyapatite phase to be the major presence when we add zinc chloride that concentration reaches 0.15M. Testing antibacterial ability by the inhibition zone method of qualitative antibacterial test methods, the results shows that ability of antibacterial increased when the concentration of zinc chloride increased from 0.0125M to 0.15M. For simulate the artificial bone, the granulated powder that after sieved prilling were coated on the surface of Ti-6Al-4V substrate by the flame-spraying method, the SEM of surface topography and cross-section found that the zinc-doped hydroxyapatite was the porous structure on the substrate, and the porosity improved significantly. The antibacterial test found the specimen has a good antibacterial ability, the inhibition rate will increase when the time contacting by the specimen and bacteria increased. For biological activity and toxicity test of the cell test, the specimen was found with good biocompatibility.
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