| Summary: | 博士 === 慈濟大學 === 醫學科學研究所 === 102 === Obsessive-compulsive disorder (OCD) is a common mental illness, usually begins in children and adolescents. The prevalence is about 2.5%. OCD, depression, and substance abuse disorders are common psychiatric disorders. Adolescence in males than females, about 2 to 1, with an average age of onset is about 20 years old, but the proportion of men and women in adulthood occurs about 1 to 1. Patients with severe OCD will spend a lot of time, and energy. Social and professional functions are severely affected. 60 to 80 percent of patients also have major depressive disorder . Medication and cognitive behavioral therapy remains the main treatment. However, 25-40 % of patients have poor outcomes. Deep brain stimulation (DBS) has been extended to the treatment of neurological and psychiatric disorders. The current small-scale human trials have some positive effects. In this thesis, we introduced OCD and related neurosurgery. We studied the acute and long-term DBS in patients with refractory OCD after IRB approved. Our results show that DBS has a certain effect on the treatment-resistant OCD. Future research will need to evaluate different parameters and possible predictors.
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