A Follow-up Study of Vascular Disease after Percutaneous Vertebroplasty for Patients with Vertebral Compression Fractures

• Main Authors: Lin, Chia-Wei, 林家偉
• Other Authors: Wen, Shu-Hui
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/a4kn6s

碩士 === 慈濟大學 === 公共衛生學系碩士班 === 102 === Vertebral compression fracture (VCF) is one of the most common osteoporotic fractures. Percutaneous vertebroplasty (PVP) is a therapeutic surgical approach performed to reduce pain in patients with VCF. Numerous studies have reported on vascular complications associated with PVP. However, there are limited studies related to the efficacy and safety of the procedure available in Taiwan. We aim to investigate the risk of vascular diseases including acute myocardial infarction (AMI), angina pectoris (AP), acute ischemic heart disease (AIHD), hemorrhagic stroke (HS), ischemic stroke (IS), venous thromboembolism (VTE) when VCF patients are treated with PVP or conservatively. VCF patients with PVP identified (n=339) and 5 age- and sex- and VCF index year-matched controls per case were chosen from a nationwide representative cohort of 800000 people from 2006 to 2010. Both groups were followed-up for vascular disease events for 1 year and 5 years with adjustments for other potential confounding factors such as comorbidities and medications, and assessed by Cox regression analysis. At 1 year follow-up, there was no statistical significance at vascular events among two groups. The probabilities of AP (5.9%), IS (8.55%) and VTE (1.47%) in the PVP group were significantly higher than in the control group at 5 year follow-up. With adjustment for demographics, comorbidities and medications, the PVP group had no significant difference with the control group in terms of any vascular events such as AMI, AP, AIHD, IS, and VTE. In conclusion, VCF patients treated with PVP are not at higher risk of any vascular disease in the next five years after the procedure.