Syntheses of transition metal complexes derived from substituted-salicylaldehyde thiosemicarbazones and mixed-ligand triphenylphosphine

• Main Authors: Yang Yu-Sheng, 楊育陞
• Other Authors: Shih Mei-Hsiu
• Format: Others
• Language: zh-TW
• Published: 107
• Online Access: http://ndltd.ncl.edu.tw/handle/28797127705791186145

碩士 === 南台科技大學 === 化學工程與材枓工程系 === 102 === Thiosemicarbazones (TSCs) reportedly have potential therapeutic activity and are widely applied in medicine especially in the treatment of tuberculosis. Various compounds with a TSC moiety also exhibit biological activity. In a number of cases, the transition metal complexes of TSC exhibit greater biological activity than the uncomplexed ligands, such as antimicrobial, antiamoebic, antitumor and anticancer activities. Hence, this observation has encouraged detailed studies on the coordination chemistry of thiosemicarbazones. This study focuses on the syntheses of special transition metal complexes derived from novel thiosemicarbazones and mixed-ligand triphenylphosphine. The text was divided into four major parts: In the first part, various substituted-salicylaldehydes were treated with various thiosmeicarbazides, such as 4-phenylthiosemicarbazide, 4-(4-methylphenyl)thiosemi- carbazide, 4-methylthiosemicarbazide and thiosemicarbazide to afford a serial of desired Schiff-base substituted-salicylaldehyde thiosemicarbazones. In the second part, the synthetheses and spectral characterization of diverse nickel complexes were discussed separately by two sections: (A) the salicylaldehyde analogues of 4-phenylthiosemicarbazones and 4-(4-methylphenyl)thiosemicarbazones were treated with nickel(II) chloride hexahydrate and mixed-ligand triphenylphosphine to afford the corresponding nickel complexes; (B) the different salicylaldehyde analogues of 4-methylthiosemicarbazones and thiosemicarbazones were treated with nickel(II) perchlorate hexahydrate in the presence of triphenylphosphine and triethylamine to obtain the desired nickel complexes. In the third part, the syntheses and spectral characterization of another transition metal complexes were studied through the reaction of thiosemicarbazones with transition metal ions, such as cobalt(II). In the fourth part, evaluation of antioxidant activity-scavenging effect on DPPH radical has been studied.