Measurement for the solubility of galic acid and propylgallate in the solvents of ethanol, propylene glycol, andN-methyl-2-pyrrolidone and their binary mixtures

• Main Authors: Chang, Hsuan-Chin, 張誌軒
• Other Authors: Tang, Muoi
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/70990435456178121595

碩士 === 中國文化大學 === 化學工程與材料工程學系奈米材料碩士班 === 102 === Solubility data of many pharmaceutical compounds are important for research topics and commercial applications, and efforts are extented to obtain a number of mathematical fitting models for solubility prediction. Gallic acid is used as inhibitor of human cell fiberization and propyl gallate is used as antioxidant in food processes. In this investigation, the solubilities of gallic acid and propyl gallate in ethanol (EtOH), propylene glycol (PG), and N-methyl-2-pyrrolidone (NMP) and their binary mixtures of EtOH+PG, NMP+EtOH, and NMP+PG were measured by a spectrophotometer at the temperatures of 303.15, 308.15, 313.15, 318.15, 323.15 K and atmopheric pressure condition. The results show that the solubility of both solids increases with increasing temperature in all pure and binary solvents. The generated data in mono-solvents at different temperatures were fitted to van't Hoff plot, the overall mean deviations gallic acid and propyl gallate in pure solvents were 1.77% and 1.94%, respectively. And the data in solvent mixtures were fitted to the Jouyban–Acree model, the overall mean deviations for gallic acid and propyl gallate in mixed solvents were 3.28% and 2.16%, respectively.