| Summary: | 碩士 === 國立臺灣科技大學 === 材料科學與工程系 === 102 === Bioactive glass (BG) has attracted the attention of researchers for the last 50 years since it firstly reported at 1971 because of the bioactivity properties, and wide potential applications such as bone implants, tooth filling materials, and drug carriers. Bioactive glass forms hydroxyapatite (HA) layers on the surface of the BG that will generate strong chemical bond with tissue when it is implanted in a human body. To increase the HA formation, one of the popular approaches is to increase the surface area of BG by synthesize mesoporous bioactive glass (MBG). One of the applications of Mesoporous bioactive glasses are as bone implants that face a major problem with bacterial infections. The growth of bacteria in the bone implant that could lead to infection could be overcome by doped MBG by antibacterial agent such as silver (Ag). Sol-gel method is the most popular procedure to synthesize Ag-doped MBG; however, this method has some drawbacks of discontinuous processing, long processing time and unsuitable for mass production. To overcome these drawbacks, spray pyrolysis (SP) is an alternative procedure to synthesize Ag-doped MBG. In this study, Ag-doped MBG was successfully synthesized by using SP with tetraethyl orthosilicate, calcium nitrate tetrahydrate, triethyl phosphate, silver acetate and silver nitrate as the Ag-doped MBG precursors. The MBG particles will be characterized by using X-ray diffraction, scanning electron microscopy, transmission electron microscopy and nitrogen adsorption/desorption isotherm for their crystallography structures, surface morphologies, and specific surface areas. Particles chemical element distributions were analyzed by using X-ray energy dispersive analysis and the dissolution profile of Ag-doped MBG is characterized using inductive coupled plasma for chemical analysis. The invitro bioactivity properties was analyzed by immersing the particles into simulated body fluid for certain hours and characterized by X-ray diffraction. Antibacterial property tests were conducted by using zone of inhibition method. Ag-doped MBG that with superior bioactivity and antibacterial properties were achieved by using the SP process, and silver distributions and particle formation mechanisms were also discussed.
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