Development of LCD Biomedical dynamic mask additive manufacturing system and fabrication of tissue engineering scaffolds

• Main Authors: Hao-lun Kao, 高浩倫
• Other Authors: Yih-lin Cheng
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/81108267036292636226

碩士 === 國立臺灣科技大學 === 機械工程系 === 102 === In recent years, many additive manufacturing related technologies have got matured increasingly. Some better process methods are provided for manufacturing better sized precise miniaturized scaffold in tissue engineering field. The shortages of conventional processes with respect to incapability of controlling size, shape and communication of holes in manufacturing scaffolds are improved. A DLP biomedical dynamic mask forming system was developed by means of photo-curing forming technology in the laboratory previously. Although the precision achieves 20?慆, the processing area is small and one-time production of large area or large quantity of scaffolds is impossible. Therefore, in this research, the liquid crystal display panel is used to replace DLP to achieve large production needs. In the research, a additive manufacturing system using LCD (liquid crystal display) panel as dynamic mask is developed in order to satisfy large area manufacturing. Also, the mask program developed previously is utilized to perform pattern output for making tissue engineering scaffolds. For main material part, PCL-diacrylate(PCL-DA) and PEG-diacrylate(PEG-DA) is mixed recipe with weight ratio as 6:4. Moreover, visible halogen lamp is selected for the system. Therefore, Irgacure784 is used instead as phpotoinitiator for material to absorb energy of visible length to generate crosslinking reaction. From the results of DSC (Differential scanning calorimetry) and TGA (thermogravimetric analysis) the condition existing human body temperature stably is still compliant. The synthesized biomedical materials may also be used in the system for making tissue engineering scaffolds. But in the material PCL-DA mixed PEG-DA in small graphical errors still occur, preliminary testing of possible factors that the processing of synthetic materials, containing organic solvents acetone and LCD panel imaging modalities.