| Summary: | 碩士 === 國立臺灣科技大學 === 化學工程系 === 102 === Even though the common therapy for AIDS, Highly Active Anti-Retroviral Therapy (HAART) has a reasonable level of success against HIV infections and HIV-related death, the problem of drug resistance from the HIV still persists. Consequently there is an ongoing need to develop new strategies and novel drugs against this.
It has been reported that silver nanoparticles (Ag NPs) with their unique anti-bacterial properties can not only overcome this drug resistance but can also inhibit the HIV protease (HIV-1 PR) in vitro. Since these particles, however, are not specific to HIV-1 PR, a search was undertaken for a peptide that is not only specific for the protease but can interact with silver nanoparticles as well and lead to enzyme inhibition. Since earlier studies suggested that silver nanoparticles have a strong attraction to sulfur, specific peptides containing one, or more, cysteine amino acids and an aromatic-hydrophobic cleavage site were synthesized.
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