| Summary: | 碩士 === 國立臺灣大學 === 護理學研究所 === 102 === Frailty is an overarching geriatric syndrome characterized by decreased reserves against stressors and may lead to vulnerability. Clinically, frailty and cardiovascular disease (CVD) often exist concurrently. The prevalence of frailty is relatively high in patients with CVD (25-50%), and undergoing cardiac surgery patients (up to 42%). Furthermore, frailty may compromise functional recovery after cardiac surgery.
In this prospective study, 100 participants undergoing cardiac surgery were enrolled and assessed at 4 time points (before surgery, 1 month, 3-month, and 6-months after surgery). Fried’s frailty phenotype, grip strength, 6-minute walking distance, lean body mass, barthel index, and Lowton IADL were assessed.
The mean age was 62.3 subjects in the study, the results were below:(1) The prevalence of frailty was 19%、35%、9.9%、8.8% ,from before surgery to 6 months after operation.(2) With the view to the trajectory of frailty, most patients belonged the unchanged frailty group .In improved frailty group, the improvement started since three months post operation and reached the peak at six months post operation. However, it had the peak at one month post operation and dropped rapidly at three months post operation in the retrograde frailty group.(3) Frailty group had significantly poorer basic daily activities than non-frailty and pre-frailty groups before and one month after operation (p<0.05) (4) Frailty group had significantly poorer instrumental activity than non-frailty and pre-frailty groups before, one and six months after operation (p<0.05). (5) There was significant different (p<0.05) between the phenotype of frailty before operation and grip strength. However, it didn’t reach statistically significant between frailty and the recovery within six months after operation.(6) Frailty group had significantly shorter 6-minute walking distance than non-frailty and pre-frailty groups before and three months after operation (p<0.05).
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