| Summary: | 碩士 === 國立臺灣大學 === 獸醫學研究所 === 102 === Spleen is the largest secondary lymphoid organ containing about one-fourth of the body’s lymphocytes in dog. Conventional surgical wisdom implies that splenic hemangiosarcoma is the most prevalent of dog splenomegaly. However, recent studies provide evidence against this. According to these studies, malignant tumor and non-malignant lesion are population of about half in dog splenomegaly. The dog spleen is composed of complex tissues: lymphoid, vascular, and other compartment, so variable tumors had be reported in dog. The retrospective study for canine splenic diseases had been not reported in Taiwan, so we want to know classification of splenic disease which have or not regional difference. Some splenic diseases present complicated lesion because spleen is the organ with complex tissue, it causes difficult to differentiate from variable spleen disease. In previous studies, some associated lesions can help pathological diagnosis.
The present study is to investigate histopathological distribution of canine spleen disease from surgical specimen in recent five years in Taiwan; and selected three common associated lesions in splenic disease: necrosis, lymphoid hyperplasia, and siderotic nodule to study correlation between the associated lesions and histopathological diagnostic type. A total of 165 cases enrolled in this studies, they were diagnosed histologically as 104 of non-malignant disease and 61 of malignant splenic tumor. Hemangiosarcoma was the most common malignant histological diagnosis (n=23). The second common was lymphoma (n=11). The percentage of hemangiosarcoma in malignant tumor are lower than previous foreign studies. The most common of non-malignant disease were splenic hematoma (n =27), and nodular hyperplasia with hematoma (n =15). The percentage of nodular hyperplasia and hematoma in non-malignant disease were also different than previous studies. Two correlation between the histopathological diagnostic type and associated lesions were significant: necrosis is more common in sarcoma type; lymphoid hyperplasia are more common in benign lesions type. In conclusion, several splenic malignant tumors and non-malignant diseases present the different population compare previous studies. It’s considered by more population small breeds in Taiwan.
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