| Summary: | 碩士 === 國立臺灣大學 === 獸醫學研究所 === 102 === The rhizomes of Gastrodia elata, have traditionally been used in Chinese medicine for seizure suppression and the treatment of insomnia. This study was performed to investigate whether T1-11, an ethanol extract (an active ingrediant) of G. elata, produces somnogenic effects in normal and insomniac rats. We further evaluated the involvement of adenosine 2A receptors (A2AR) and adenosine 1 receptors (A1R) in the T1-11-mediated somnogenic effects. Administration of T1-11 increased non-rapid eye movement (NREM) sleep. The amount of rapid-eye movement (REM) sleep was not significantly changed. 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective A1R antagonist, did not block the T1-11-induced enhancement of NREM sleep, whereas 5-amino-7-(β-phenylethyl)-2-(8-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine (SCH 58261), a selective A2AR antagonist, significantly blocked the T1-11-induced enhancement of NREM sleep, indicating the role of A2AR in the somnogenic effect of T1-11. T1-11 increased NREM in the insomniac rats, providing evidence for the potential use of T1-11 in the treatment insomnia in clinic.
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