Single-shot proton MR spectroscopic inverse imaging

• Main Authors: Yi-Ting Hsu, 許依婷
• Other Authors: 林發暄
• Format: Others
• Language: en_US
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/39807869659281506153

碩士 === 國立臺灣大學 === 醫學工程學研究所 === 102 === Magnetic resonance spectroscopy (MRS) is a non-invasive technique that has been used to investigate the metabolic changes in living tissues. Fast magnetic resonance spectroscopy imaging (MRSI) using the proton-echo-planar-spectroscopy-imaging (PEPSI) technique can provide spatial distribution of metabolites in one single radio-frequency (RF) excitation. This method significantly reduces the scan time of 2-dimension MRSI down to 1 minute. Inverse imaging (InI) uses a highly parallel RF coil array to achieve 100-millisecond temporal resolution with the whole brain coverage. Combining PEPSI sequence with InI can further accelerate the MRSI data acquisition. InI reconstruction utilizes coil sensitivities to reconstruct the omitted partition/phase encoded data by solving an under-determined inverse problem. This study shows that the acceleration rate of the combined PEPSI and INI method is not as fast as expected. Specifically, using a 32-channel head coil array, we can achieve up to 6-fold acceleration in 2D PEPSI. Such scan time reduction can still increase the potential of applying MRSI to clinical applications.