Effects of Natural Killer Cells with/without β-Glucan on Insulin Resistance and Immunity in STZ-induced Diabetic Mice
碩士 === 國立臺灣海洋大學 === 食品科學系 === 102 === Diabetes mellitus is characterized by high blood glucose level. Hyperglycemia has been identified as the main factor contributing to the development of diseases associated with diabetes mellitus. Diabetes is widely believed to predispose to serious infections. B...
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| Format: | Others |
| Language: | zh-TW |
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2014
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| Online Access: | http://ndltd.ncl.edu.tw/handle/2yv4y2 |
| Summary: | 碩士 === 國立臺灣海洋大學 === 食品科學系 === 102 === Diabetes mellitus is characterized by high blood glucose level. Hyperglycemia has been identified as the main factor contributing to the development of diseases associated with diabetes mellitus. Diabetes is widely believed to predispose to serious infections. Beta glucans are now recognized as potent immunological activators. Glucose metabolism disorders influence anticarcinogenic function of natural killer cells (NK cells). On the other hand, both oat and fungal beta-glucans reduce blood glucose concentrations after oral administration in animal experiments and clinical trials. The aim of study is to investigate the beneficial effect of natural killer cells on diabetic mice. Female BALB/cByJNarl and C57Bl/6JNarl mice were induced diabetes by streptozotocin. NK cells were cultivated in vitro and injected with different concentrations of NK cells into diabetic mice. The results showed that treatment of NK cells significantly improved the hyperglycemia and insulin resistance. But there were no differences at antioxidant enzymes and immunity evaluations. This study demonstrated NK cells can protect mice from diabetes, and NK cells therapy may decrease diabetic symptoms in future.
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