| Summary: | 碩士 === 國立臺灣師範大學 === 機電工程學系 === 102 === For environmental monitoring and point of care (POC), the biological specimen culture and testing are an important technology. However, the requirement of space conditions for its high specification and heavy equipment is difficult for a wide range of flexible use. Over the past decade, the biochips combined with electronic, mechanical and biological technology that can perform a rapid analysis of biological samples under different environmental conditions. The aim of study is to design microfluidic system device with the simulation method for trapping channel structures in the microfluidic transportation system. Based on the fluid simulation results, the distribution of the pressure fields, velocity fields and its flow behaviors are obtained that can be useful to fabricate the suitable devices. It can be seen the reasons that probably affect the trapping efficiency such as the influence of mciroflow resistance on the moving path and the influence the accumulation phenomenon on negative pressure zone.
The experimental simulation results show the trapping efficiency is not well when the microparticles (≦50 m) run through the U-type structures in the microfluidic device. Because of the high-speed flow, the microparticles are easily induced them to pass the design of structures. Simultaneously, the single capturing structure can easily capture over one microparticle to cause the accumulation phenomenon occurs at the higher negative pressure. Consequently, this study proposes new type design of triangular structures in order to make the uniform flow, fill in the structure with particles and reduce the negative pressure. And the single structure can achieve to capture and the single particle. The capture particles size including the droplet (100 15 m) and polymer microsphere (25 5 m) can be used in this study. The trapping efficiency of droplets for design of triangle and the U-shaped structures is close whose the capture rate is over 95%. Furthermore, the trapping efficiency of polymer microspheres for triangular structured and U-type structured devices are 42.9% and 9%, respectively.
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