The anti-nociceptive effects of a marine-derived peptide in neuropathic rats

• Main Authors: Chang-yi Liao, 廖倉億
• Other Authors: Zhi-Hong Wen
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/p658u5

碩士 === 國立中山大學 === 海洋生物科技暨資源學系研究所 === 102 === In recent years, marine organism-derived peptides have been identified as new and potential sources for drug development. Recently, we found that the marine organism-derived peptide, PCD-1 was biologically active, and previous studies have indicated that it have anti-inflammatory properties. The neuroinflammatory processes are known to play a critical role in the development and maintenance of neuropathic pain, for which no effective drugs are currently available. In the present study, we investigated the anti-analgesic and anti-neuroinflammatory effects of the PCD-1 on chronic constriction injury-induced neuropathy in rats. We found that intrathecal injection of PCD-1 produced a significant and dose-dependent inhibition of thermal hyperalgesia, mechanical allodynia, weight bearing, and cold allodynia in neuropathic rats after CCI surgery. Moreover, it also attenuated CCI-induced spinal neuroinflammation. On the basis of these experimental results, we suggest that PCD-1 could be used as a potential therapeutic agent for neuropathic pain.