| Summary: | 碩士 === 國立宜蘭大學 === 食品科學系碩士班 === 102 === Poria cocos is an edible and medicinal fungi, the main bioactive compounds are polysaccharides and triterpenoids. The pharmacological studies confirmed that it has several effects such as anti-inflammatory, antioxidant, immunomodulatory, anti-tumor, hypoglycemic, sedative, diuretic, antiemetic etc. The objectives of this study were (1) to explore the microwave power, extraction time of the crude polysaccharides and triterpenoids content in the Poria cocos solid-state fermented products, and to compare its extraction efficiency with hot water extraction and ultrasonic extraction, and (2) to study hypoglycemic function of the crude Poria cocos extracts. The results showed that the highest crude polysaccharides and triterpenoids contents were in Poria cocos solid-state fermented adlay and soybean, respectively. The solvents used for extracting crude polysaccharides and triterpenoids were water and 95% ethanol, respectively. The solid-liquid ratio was 1:20. The optimal microwave extraction was controlled the microwave output power at 300 W heating for 5 min. Both STZ-induced diabetic mice (type I diabetes) and STZ with NA-induced diabetic mice (similar to type II diabetes) by tube-feeding 50 mg/kg ethanol extracted from Poria cocos solid-state fermented soybean product had good hypoglycemic effec.
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