Studies on the Sesterterpenoids from the Formosan Sponge Luffariella sp.

• Main Authors: Zuo-Jian Liao, 廖佐健
• Other Authors: Jui-Hsin Su
• Format: Others
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/38p4uc

碩士 === 國立東華大學 === 海洋生物科技研究所 === 102 === Marine sponges of the genus Luffariella are now known to be a rich source of novel sesterterpenes. Some of these sesterterpenes display a wealth of biological activities, such as cytotoxic, and anti-inflammatory. The current chemical investigation of Luffariella sp. led to the discovery of six new sesterterpenes, luffalides A─F (1─6), as well as the five known compounds, luffariellin B (7), 25-acetoxyluffariellin A (8), manoalide monoacetate (9), Z-24-acetoxyneomanoalide (10) and (6E)-neomanoalide-24,25-diacetate (11). The structures of these compounds were elucidated on the basis of their spectroscopic data. Among these metabolites, compounds 1─5 are rarely found in monocarbocyclic sesterterpenoids possessing a 1-isopropenyl-2-methylcyclopentane ring system. Compounds 2─11 were tested in vitro for cytotoxicity against HL-60, Molt-4, K562, T47D and LNCaP cancer cells. The results show that compounds 7─9 were found to exhibit inhibition against the growth of HL-60, Molt-4, K562, T47D and LNCaP cancer cells. It seems that the α-hydroxybutenolide or α-acetoxybutenolide moiety in compounds 7─9 is critical for the cytotoxic activity of the monocarbocyclic sesterterpenoids.