Study of functions of MAPK signaling pathway related microRNAs in melanoma cells

• Main Authors: Yen-Pu Chang, 張言溥
• Other Authors: Nianhan Jia-Lin Ma
• Format: Others
• Language: en_US
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/q57693

碩士 === 國立中央大學 === 系統生物與生物資訊研究所 === 102 === It has been reported that approximately 50-70% of melanoma samples contain BRaf mutations, 80% of which is V600E. The mutation constitutively induces high activity in MAPK/ERK signaling pathway and causes malignant phenotypes of cancers. MAPK/ERK signaling may be modulated by microRNA (miRNA); however, correlations between miRNA, melanoma and MAPK/ERK pathway are still unclear. We screen out MAPK-related miRNA from the prior microarray results and GEO data analysis. For further investigation, experiments should be performed in vivo in the future. Elucidating the role of miRNAs in melanoma may provide as biomarkers or a miRNA-targeting therapy for cancers.