Biomimetic Taste Receptors with Chiral Recognition by Photoluminescent Metal-Organic Frameworks Chelated with Polyaniline Helices

• Main Authors: Tsung Yan Lin, 林宗諺
• Other Authors: Tu Lee
• Format: Others
• Language: en_US
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/53dmz5

碩士 === 國立中央大學 === 化學工程與材料工程學系 === 102 === In the area of measurement technology, the methods for getting information about a process have changed. There is an urgent need for non-specific detections. Processes in food, beverage, and pharmaceutical industries, even the environment monitoring have demands for real-time measurements to ensure the optimal processes. In nature, taste perception is one of the critical senses besides vision, hearing, and olfaction in mammals. It dominates the preference of food intake behaviors. Mammals can detect whether the chemical components in a potential food are vital or fatal by so called “flavors”. This natural sensor can distinguish up to 5000 tastes by combinations of five basic tastes (sweet, umami, bitter, sour, and salty). There were various kinds of artificial sensors designed under the concept of biological receptors in human and other mammals. Most of these sensor arrays based on potentiometric or voltammetric signals were called e-tongues. In our previous work, a biomimetic tongue was demonstrated by the sensor arrays through poly(acrylic acid) chelated [In(OH)(bdc)]n, [In(OH)(bdc)]n, and MOF-76. Unfortunately, this sensor arrays could not distinguish the difference between enantiomers. We thus want to upgrade the biomimetic receptor by introducing polyaniline, a helical optical-active polymer. There are several significances in this research: (1) the subtle differences between D-phenylalanine and L-phenylalanine could be discriminated by the different photoluminescence responses, (2) the working principles, and interaction modes of (+)-polyaniline chelated [In(OH)(bdc)]n microcrystals were deduced and proposed in detail, (3) it was considered a biomimetic functional material because the behavior of this material was analogous to G-protein coupled receptors in mammals, (4) by introducing various kinds of polymers and made them into sensor arrays, different tastants could be recognized through their own distinct 2-D signal patterns constructed by the photoluminescence responses.