Detection Platform of Cell Migration using CMOS Image Sensor

• Main Authors: He, Ren-Ruei, 何仁睿
• Other Authors: Sheu, Meng-Lieh
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/56670018536844468341

碩士 === 國立暨南國際大學 === 電機工程學系 === 102 === This thesis presents a cell migration sensor chip which contains CMOS image sensor array (CIS) and a successive approximation register (SAR) ADC. The migration activity of living cells placed directly on the surface of the image sensor chip is converted into electronic signal by the sensor chip. The fixed-pattern noise is removed through correlated double sampling circuit. The SAR ADC is then employed to convert the sensed signal into digital format for displaying, storage and analysis on the detection platform. To verify the cell migration sensor chip, a prototype chip with 8×8 image sensor array is implemented using TSMC 0.18μm 1P6M CMOS process provided by CIC. The CMOS image sensor has a fill factor of about 67.85% and consumes less than 60.76μW. The measurement results of the ADC show that the SNDR and ENOB are 51.46dB and 8.26-bit, respectively, at 2MS/s sampling rate and 52.897k Hz input frequency with power consumption of 108.41μW at 1.8V supply voltage. The FOM is 169.77 fJ/conversion. The whole chip area is 880μm×880μm, and the power consumption is less than 169.17μW.