Design and fabrication of contactless capacitively-coupled biochip and its application to whole blood separation and glycemic analysis

• Main Authors: Po-HsiuLin, 林伯修
• Other Authors: Chen-Kuei Chung
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/9hpq7s

碩士 === 國立成功大學 === 機械工程學系 === 102 === The core value of point-of-care is to create a platform that combines many critical techniques in a micro-chip included “transportation”, “application” and “detection” which is the goal of this thesis. A plasma separating biochip is designed and demonstrated using capillary-driven contactless capacitively-coupled method. The long-term capillary drive force was produced by hydrophilic surface of the chip. With low voltage (~1 V) and high frequency induced electrostatics between the red blood cells. The polarized red blood cells were aggregated and separated from plasma with high volume separation and 89.4% removal rate of red blood cells. Combined the Pt detect electrode in the very end of the channel, the glucose concentration in the separated plasma was detected with good results.