| Summary: | 碩士 === 國立成功大學 === 化學工程學系 === 102 === SUMMARY
In this study, we report the preparation of cross-linked polypeptide complex micelles, cross-linked polypeptide nanocages, and silica/polypeptide hybrid nanoshells templated by metal ion-polyelectrolyte assemblies via electrostatic interaction. The complex micelles composed of poly(diethylenetriaminepentaacetic dianhydride-co-cystamine) (poly(DTPA-co-cysam)), metal ions, and PEG-b-poly (L-lysine) (PEG-b-PLL) exhibited redox/pH dual-responsive property. Their sizes can be tuned by varying the molar ratio, metal ion species, or synthesis process. These complex micelles can be cross-linked by genipin to prevent dissociation upon dilution. The cross-linked polypeptide nanocages can be prepared and used as template to form silica/polypeptide hybrid nanoshells. Furthermore, these cross-linked micelles were employed for doxorubicin (DOX) encapsulation and it was found that the DOX release can be triggered by redox/pH dual-responsiveness. These complex micelles could be promising as drug carriers.
Keywords : nanocage, nanoshell, silica, redox/pH responsiveness, drug delivery, cross-linked, polypeptide
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