Effect of ultrasonic water extracts of Cordyceps cicadae and Acremonium sp. mycelium (AH888) on cisplatin-induced acute kidney injury in rats

• Main Authors: Ming-Chien Wang, 王明乾
• Other Authors: Gow-Chin Yen
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/73484355927178568244

碩士 === 國立中興大學 === 食品暨應用生物科技學系所 === 102 === Cisplatin is one of potent tumor suppressor compounds, by its main mechanism of action of DNA cross-linked inhibition of cell replication and division, resulting in tumor cell apoptosis and necrosis. However, the limit of application of cisplatin on clinical treatment occurred due to its side effects, such as kidney injury. Cordyceps cicadae is a fungus which attacks insects or a fungus insect complex including cicada larvae by Paecilomyces cicadae. Moreover, Cordyceps cicadae may possess potential to improve kidney disease. This study was aimed to evaluate the effect of ultrasonic water extracts of Cordyceps cicadae (WECC) and ultrasonic water Acremonium sp. mycelium (WEAM) on SD rats with cisplatin-induced acute kidney injury. Rats were intraperitoneally injection with cisplatin (1 mg/kg of B.W.) on the 1st day, 3th day, 6th day, 9th day, 12th day, 16th day. On day 17, 0.9% saline by oral gavage (C group), WEAM at 310 mg/kg of B.W. (CA group) and WECC at 930 mg/kg of B.W. (CC group) were treated until the 44th day. The results showed that the levels of serum blood urea nitrogen (BUN), creatinine and urinary protein, survival rate and histological examination showed no significant difference in WECC and WEAM groups compared to the cisplatin group. However, a slight decrease of kidney injury molecular-1 (KIM-1) level in kidney tissues was observed in the WEAM treated rats. In conclusion, WECC and WEAM might be a limited improve on renal damage caused by cisplatin.