| Summary: | 碩士 === 國立中興大學 === 生物醫學研究所 === 102 === Flavonoids are major ingredients of citrus peel and known to have health beneficial properties. Polymethoxylflavones (PMFs), a class of flavonoids, exist almost exclusively in citrus peel and have been demonstrated with wide range of biological activities. Studies have reported that PMFs function as anticancer and chemopreventive agents via the inhibition of metabolic activation of procarcinogens,antioxidant activity, reducing DNA damage and suppression of tumor growth by activating apoptosis or inhibiting intracellular signaling thus blocking cell cycle
progression. Gold lotion (GL), a formulated product made from the peels of six citrus fruits in Japan, was originally marketed for cosmetic use for protection of skin from UV irradiation. Subsequently, studies have reported that its anticancer property for melanoma, prostate cancer, lung cancer, and liver cancer without toxicity effect by skin application and oral ingestion. The recent studies has anti-inflammatory and
immunomodulatory effects. However, to the best of our knowledge, the cellular and molecular targets of GL in the immune system have remained unclear. Dendritic cells
(DCs) are potent antigen presenting cells that control both innate and adaptive immune systems. In our study, we investigated the ability of GL on the maturation
and function of dendritic cells (DCs). Furthermore, to explore more the potential health beneficial effect of GL, here we report the bioactivity of GL by oral
administration in an animal model. The oral administration of GL attenuated the 2,4-Dinitro-1-fluorobenzene induced contact hypersensitivity (CHS) in animal models.
These findings report to provide new insight in the immunopharmacological role of GL in terms of its effects on DC, and impacts, the function of DCs and may have
potential therapeutic applications against harmful immune responses.
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