Motivations of diabetes patients who participate clinical trials -- Comparisons between the participation group and refusal group

• Main Authors: Hui-Ying Lee, 李憓盈
• Other Authors: Wayne Huey-Herng Sheu
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/j5ph4d

碩士 === 國立中興大學 === 生命科學院碩士在職專班 === 102 === Purpose: Diabetes has become major health and economic burden in developing and developed countries. Many pharmaceutical companies are engaging new diabetes treatment drugs discovery and thus a high demanding of diabetes subjects to participate new drug clinical trials. The aim of this study is to investigate the motivations that diabetes subjects who are willing to participate a clinical trial. Method: Diabetes outpatients with diabetes from a medical center in Taichung were recruited after obtained written consent. A total of 61 diabetes patients were enrolled. They were divided into those who ever participated (n=30) or refused (n=30) to participate a clinical trial. Demographic characteristics, social-economic status and questionnaires were collected to evaluate their personal traits, motivation, knowledge, and attitudes toward participating a clinical trial. Results: As compared with patients who refused to participate a clinical trial refusal group, patients in participation group were more male (87% vs.42 %, p=0.001), and lower proportion to have religious belief (57% vs. 84%, p=0.041). The main reason to participate a clinical trial was “to promote medical progress” and “uncertainty about adverse effects and safety”, respectively. Patients who joined clinical trials were more knowledgable (p<0.001) and had positive attitude (all p<0.01) toward clinical trials than those in refusal group. Results of logistic regression analysis showed that the independent predictors for patients to join a clinical trial were male sex, no religious belief, more knowledgable, and positive attitudes toward clinical trials. Conclusion: we revealed predictors for patients to join a clinical trial were male sex, more knowledge, and positive attitudes toward clinical trials. Our findings may be useful for future recruitment of clinical trials.