| Summary: | 碩士 === 國立中興大學 === 化學工程學系所 === 102 === In transdermal drug delivery, the stratum corneum is the enormous resistance. To effectively permeate the drug into the human skin, the studies had been proposed after the approaches of permeable enhancement had researched. These approaches was categorized to chemical and physical. Recently, the dramatical approach which was physical enhancement, can pierce the stratum corneum with microneedles. Because it directly crossed the permeability barrier, accompanied the coated drug can effectively get into the human body. Literature reported that used the biodegradability materials to fabricate the microneedles and the drug was encapsulated within the microneedles. In this way, it can not only assist the drug delivery, but also control drug release at targeting site. And it was without pain or biohazardous in human body.
By this literature, the approach with microneedles can pierce the stratum corneum such that the drug get into the body without resistance. If used dissolved microneedles, then increased the controlled drug release function and without pain and hurt for human. Therefore, this work used a mathematicl two-dimensional model accounting for drug diffusion with microneedles array and fixed the number of microneedles to compare that increased the points in one direction more than other will have the best effective, as well as, compared to single microneedle. Among of different arrangements, the diffusion with increasing the number of microneedles in the direction of ρ was more effectively than the direction of θ. Finally, all of the arrangement with many microneedles were better than the model with single microneedle.
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