| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所 === 102 === Objective
This study was to investigate the prescribing patterns of Schizophrenia patients and present the incidence of schizophrenia ( ICD-9-CM 295 ) in Taiwan. The aim was to offer evidenced-based data for prescribing medical selection.
Background
Schizophrenia is among the most disabling and economically catastrophic medical disorders, ranked by World Health Organization as one of the top ten illnesses contributing to the global burden of disease. Antipsychotic drugs are first-line treatment for schizophrenia; however, antipsychotics differ widely in their side effect profiles, influencing drug selection. Because of the complex medical selection for individuals, this study investigated the prescription of medications to treat Schizophrenia under NHI in Taiwan.
Subjects and methods
The data for 2006 to 2010 were collected from the NIHD. The dataset contains information about 1,000,000 beneficiaries randomly sampled from the year 2006 registry for beneficiaries of the NHIRD. The subjects were grouped by age classified in to one of five categories and identified based on major diagnoses of ICD-9-CM codes 295 ( included the first diagnostic code 295 without second or third code).
Result
Subjects based on the ID included were 2,486(male 1,231 and female 1,255) in 2006~2010. The incidence of male and female was no statistical difference (P = 0.369).The analysis of initial prescription items of Schizophrenia patients in 2007~2010 shows the patients with any one of antipshychotics or without any one were 97.43% and 2. 57%. The average numbers of drugs for prescribing patterns were 2.7.The incidence of schizophrenia (ICD-9-CM:295) grouping by age gap,<18, 18-29, 30-44, 45-64, and 65 or more years were 2.37%, 19.03%, 42.08%, 31.74% and 4.79%. The rate of the medication analysis of the initial diagnosis prescriptions –one drug, two drug, and three drug separately were 23%, 29%, 23%. There were most of patients to Schizophrenia therapy in Metropolitan Hospitals, 373 persons (43.63%), in 2007-2010. The most prescribing patterns of one drug were N05AX-other antipsychotic, 90 persons (50.56%)
The prescribing patterns of two drugs for the treatment of adverse effect were [(N05A) +(N04A), (N05A) + (N05B), (N05A) + (C07B), (N05A) + (A06A)] and total subjects were 109 persons (46.19%).
Conclusions
The results of this study shows that after the initial diagnosis of psychosis patients (ICD-9: 295), about 2.57% of patients in the treatment of prescription without antipsychotic. The medications of prescription were 1~3 drugs.
(73.6%). The type of drugs to be most prescribed in two drugs group were Antipsychotics and Hypnotics and sedatives [(N05A) + (N05C)]. There was Antipsychotics, Hypnotics and Sedatives and Anticholinergic agents [(N05A) + (N05C) + (N04A)] in three drugs group.
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