| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所 === 102 === Aim：The study mainly discussed the Compounding-Sterile Preparations of Total Parenteral Nutrition Solutions (TPN), Chemotherapy
Preparations (CT) and Radiotherapy Preparations (RT) for better
understanding actual processing situation and to further ensure the safety
of patients medication.
Methods：The study organized questionnaires and site-visit checking forms aiming at the operation environment, personnel training, operation
evaluation and S.O.P setting of hospitals for compounding-sterile
preparations. The content of “Compounding-Sterile Preparations
Operation Environment Questionnaire” was designed and processed in
the hospitals which apply all of Total Parenteral Nutrition Solutions
,Chemotherapy Preparations and Radiotherapy Preparations
.The site visiting checking points include environment and
equipment of compounding area, the setting of S.O.P. and quality
control monitoring. Collecting the actual operation situation information
nowadays with further data analysis facilitates the understanding of
actual processing of compounding-sterile preparations.
Results：There are totally 58 hospitals apply Total Parenteral Nutrition
Solutions, Chemotherapy Preparations and Radiotherapy
Preparations at the same time, one of them refused to take the
questionnaire while 57 hospitals information were collected. The
questionnaire return-rate was 98%. One of the 57 hospitals refused site
visiting and 56 hospitals information were collected. The site-visiting
perform rate was 98%. The results indicated that Total Parenteral
Nutrition Solutions was operated in strictly controlled environment
in 55 hospitals while 2 hospitals operated the compounding in
air-conditioning environment. For Chemotherapy Preparations, the
procedure was operated under controlled environment in 56 hospitals and
one in air-conditioning environment. For Radiotherapy Preparations,
11 hospitals processed in well-controlled environment, 7 in
air-conditioning environment, 5 in uncertain environment and 32
hospitals with no response in questionnaires. The results of site visiting
indicate that 48 hospitals operated the compounding procedure in
controlled environment and one in air-conditioning environment.
56 hospitals operated chemotherapy infusion compounding in
controlled environment. Regarding Radiotherapy Preparations, only
8 hospitals responded with actual answers in questionnaires (7 in
air-conditioning environment and one in controlled environment) while
32 hospitals purchase the Preparations, 4 without filling in the answers, 6 without intervention and 6 didn’t set the operation location.
Conclusion：Due to the present hospitals regulations, the hospitals
investigated in the study provided enough aseptic equipment and effective
protection for Total Parenteral Nutrition Solutions and Chemotherapy
Preparations. The aseptic environment for Radiotherapy Preparations
which was not included in the hospital accreditation needed to be
improved. However, most hospitals in the study chose out-sourcing and
purchased the Radiotherapy Preparations. The operation procedure and
environment were unknown. Therefore, it is necessary for the hospitals
requiring qualified aseptic environment and compounding procedure.
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