Efficient Microwave-Assisted Palladium-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Alcohols

• Main Authors: Bai-Jing Peng, 彭百竟
• Other Authors: Shyh-Chyun Yang
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/tgfg45

碩士 === 高雄醫學大學 === 藥學研究所 === 102 === A principal goal of organometallic chemistry is the catalytic synthesis of organic compounds by using the chemistry of organic ligands covalently bound to transition metals. The palladium-catalyzed allylation of N-nucleophiles was an established and efficient method, which has been widely applied to organic chemistry. Utilizing the prevalence of indole nucleus in biologically active compounds, the direct C3-functionalization or N-functionalization of 2,3-disubstituted indoles represent an important problem. In this study, the palladium-catalyzed 2,3-disubstitued indoles with allylic alcohols in benzene was investigated under various conditions. Furthermore, microwave has been widely applied to shorten reaction time in organic synthesis. Herein, we develop a new highly selective method. This method provide particularly convenient, efficient, and selective.