Utilizing the Oxidation of Terminal Alkenes andIntramolecular Cyclization:(1) Synthesis of 2-Naphthols from o-Allylbenzaldehydes(2) Synthesis of Isoquinolin-1(2H)-ones fromo-Allylbenzonitriles

• Main Authors: Fu-Liang Lu, 呂福量
• Other Authors: Eng-Chi Wang
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/e872ah

碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 102 === Chapter 1 A novel synthesis of substituted 2-naphthols is disclosed. The o-allylbenzaldehydes, prepared from isovanillin through three synthetic steps, were reacted with PdCl2/CrO3/NaOH in water to undergo a tandem reaction sequence, including oxidation and intramolecular cyclization to yield 2-substituted naphthols in excellent yields. Chapter 2 A novel synthesis of substituted isoquinolin-1(2H)-ones is disclosed. The o-allylbenzonitriles, prepared from isovanillin through five synthetic steps, were reacted with PdCl2/CrO3/NaOH in water to undergo a tandem reaction sequence, including oxidation and intramolecular cyclization to yield of substituted isoquinolin-1(2H)-ones in excellent yields.