Synthesis and Biological Evaluation of Benzimidazoisoquinoline, Pyrazoloquinoline and Isoxazoloquinoline Derivatives

碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 102 === This thesis describes synthesis and antiproliferative evaluation of certain potential DNA intercalating agents such as benzimidazoisoquinoline, pyrazoloquinoline, and isoxazoloquinoline. Among them, compound 26d which is one of the 2,5-disubsituted benzimidaz...

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Main Authors:	Chia-Yang Hung, 洪家揚
Other Authors:	Cherng-Chyi Tzeng
Format:	Others
Language:	zh-TW
Published:	2014
Online Access:	http://ndltd.ncl.edu.tw/handle/av7u42

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spelling	ndltd-TW-102KMC055370022019-05-15T21:43:12Z http://ndltd.ncl.edu.tw/handle/av7u42 Synthesis and Biological Evaluation of Benzimidazoisoquinoline, Pyrazoloquinoline and Isoxazoloquinoline Derivatives 苯并咪唑異啉、吡唑喹啉與異噁唑喹啉衍生物之合成及生物活性評估 Chia-Yang Hung 洪家揚碩士高雄醫學大學醫藥暨應用化學研究所 102 This thesis describes synthesis and antiproliferative evaluation of certain potential DNA intercalating agents such as benzimidazoisoquinoline, pyrazoloquinoline, and isoxazoloquinoline. Among them, compound 26d which is one of the 2,5-disubsituted benzimidazole dertivatives, possessed the most potent antiproliferative activity against human liver cancer cell (Huh-7) with an IC50 value of 6.21 μM. We have also synthesized the derivatives of pyrazoloquinoline and isoxazoloquinoline,with an aim to improve the selectivity and specificity of the compounds against the growth of various cancer cells. Cherng-Chyi Tzeng 曾誠齊 2014 學位論文 ; thesis 94 zh-TW
collection	NDLTD
language	zh-TW
format	Others
sources	NDLTD
description	碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 102 === This thesis describes synthesis and antiproliferative evaluation of certain potential DNA intercalating agents such as benzimidazoisoquinoline, pyrazoloquinoline, and isoxazoloquinoline. Among them, compound 26d which is one of the 2,5-disubsituted benzimidazole dertivatives, possessed the most potent antiproliferative activity against human liver cancer cell (Huh-7) with an IC50 value of 6.21 μM. We have also synthesized the derivatives of pyrazoloquinoline and isoxazoloquinoline,with an aim to improve the selectivity and specificity of the compounds against the growth of various cancer cells.
author2	Cherng-Chyi Tzeng
author_facet	Cherng-Chyi Tzeng Chia-Yang Hung 洪家揚
author	Chia-Yang Hung 洪家揚
spellingShingle	Chia-Yang Hung 洪家揚 Synthesis and Biological Evaluation of Benzimidazoisoquinoline, Pyrazoloquinoline and Isoxazoloquinoline Derivatives
author_sort	Chia-Yang Hung
title	Synthesis and Biological Evaluation of Benzimidazoisoquinoline, Pyrazoloquinoline and Isoxazoloquinoline Derivatives
title_short	Synthesis and Biological Evaluation of Benzimidazoisoquinoline, Pyrazoloquinoline and Isoxazoloquinoline Derivatives
title_full	Synthesis and Biological Evaluation of Benzimidazoisoquinoline, Pyrazoloquinoline and Isoxazoloquinoline Derivatives
title_fullStr	Synthesis and Biological Evaluation of Benzimidazoisoquinoline, Pyrazoloquinoline and Isoxazoloquinoline Derivatives
title_full_unstemmed	Synthesis and Biological Evaluation of Benzimidazoisoquinoline, Pyrazoloquinoline and Isoxazoloquinoline Derivatives
title_sort	synthesis and biological evaluation of benzimidazoisoquinoline, pyrazoloquinoline and isoxazoloquinoline derivatives
publishDate	2014
url	http://ndltd.ncl.edu.tw/handle/av7u42
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Synthesis and Biological Evaluation of Benzimidazoisoquinoline, Pyrazoloquinoline and Isoxazoloquinoline Derivatives

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