| Summary: | 碩士 === 高雄醫學大學 === 臨床醫學研究所 === 102 === Lung cancer is the leading cause of death related to cancer in the world today. In Taiwan, lung cancer is also the malignancy that is a major cause of death. Investigating the mechanism of apoptosis of lung cancer is very important to the treatment of lung cancer. In this study, we first demonstrated that isolinderalactone has anticancer effects in human non-small cell lung cancer A549 cells. We assayed the effect of isolinderalactone on apoptosis, cell cycle distribution p21 levels, Fas receptor and soluble Fas ligand (sFasL) to survey the mechanism of isolinderalactone’s anticancer effect. Finally, we proved that isolinderalactone can induce p21, and then cause the cell cycle arrest of A549 cells. Our data also showed that the Fas/sFasL apoptotic system plays an important role in the mechanism of isolinderalactone-induced apoptosis of A549 cells. These novel findings demonstrate that isolinderalactone can cause the cell cycle arrest of A549 cells by induction of p21 and induce apoptosis of human NSCLC A549 cells through the Fas/sFasL- mediated apoptotic pathway activation.
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