| Summary: | 碩士 === 高雄醫學大學 === 牙醫學研究所 === 102 === Object:
The purpose of this study is to investigate the relationship of IL-6 -572 C/G、IL-10-592 T/G and chromosome 9P21.3 gene polymorphism in periodontitis and cardiovascular disease.
Materials and methods:
According to the result of cardiac catheterization and CT scan and number of artery stenosis, we divided 222 patients whom had cardiovascular disease into 3 group. We also recorded the periodontal status including the numbers of missing tooth, probing depth, clinical attachment loss, bleeding on probing and plaque record. Single nucleotide polymorphisms were based on samples of IL-6 -572 (rs1800796), IL-10 -592 (rs1800872), 9P21.3 (rs10757278) gene polymorphism analysis. The relationship between single nucleotide polymorphisms, periodontitis and cardiovascular disease were analysed.
Result:
Three artery stenosis group had more tooth loss, higher average loss of clinical attachment level and higher level of clinical attachment loss ≧ 5 mm percentage. There were statistically significantly higher levels of clinical attachment loss and loss of clinical attachment level ≧ 5 mm percentage in group whom with history of myocardial infarction than that with no history of myocardial infarction.IL-6 -572 G genotype has a protective effect on severity of periodontoitis and gender, history of diabetes, pack-year> 30 had statistically significantly association with heart artery stenosis. But single nucleotide polymorphisms did not reach a statistically significant correlation with heart artery stenosis.
Conclusion:
The results indicated that there were more advanced periodontal breakdown in more artery stenosis group and with history of myocardial infarction group.IL-6 -572 G genotype has a protective effect on severity of periodontitis but single nucleotide polymorphism did not reach a statistically significant correlation with severity of more artery stenosis and with history of myocardial infarction.
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