Investigation of the Non-Invasive Measurement of Arterial Endothelial Vasodilatation

• Main Authors: Jia-Fu Yang, 楊家福
• Other Authors: Jia-Jung Wang
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/32875488287811947679

碩士 === 義守大學 === 生物醫學工程學系 === 102 === Vascular endothelial dysfunction has been shown to be an early indicator of atherosclerosis as well as a risk factor of cardiovascular disease. In the clinical trials, 33 subjects (Control group: N=26, Patient group: N=7) were recruited and asked to undergo a 5-minute occlusion of the brachial artery. The flow-mediated dilatation (FMD) was assessed by the air cuff oscillometry, the photo-plethysmography (PPG) and the ultrasound, respectively. Another 30 normal and young participants were asked to perform 1, 3 and 5-minute occlusion of the brachial artery to observe the occlusion effects on FMD. Experimental results showed that the oscillometry-based FMD of the radial artery was significantly greater in the Control group than in the Patient group (129±35 vs 92±31 %, p=0.009). However, there was no significant difference in the PPG-based FMD of the finger artery together with microcirculation between the two groups. After the 5-minute occlusion, the Control group had significantly larger maximum reaction time than that in the Patient group (54±10 vs 23±6 sec, p<0.001). For the 30 normal and young participants, their FMD through a 3-minute occlusion of the brachial artery was significantly smaller than that through a 5-minute occlusion (p<0.001), but not with that through a 1-minute occlusion. In summary, the proposed air cuff oscillometry can be used to effectively assess the endothelial FMD of a conduit artery.