| Summary: | 碩士 === 中臺科技大學 === 藥物科技研究所 === 102 === The metabolic syndrome has received a great attention in recent years. The diet with high calories is considered as the risking factors for obesity, hypertension, high triglycerides and hyperglycemia. Dioscorea opposita had been reported to have beneficial effects on diabetes in ancient Chinese pharmacopoeia. We screened four hundred herbal extracts and found Dioscorea opposita extract could improve blood sugar level significantly. The purpose of this study was to investigate how Dioscorea opposite to regulate blood sugar. In cell experiments, the phosphorylations of AMPK (AMP-activated protein kinase) and ACC (acetyl-CoA carboxylase) were increased in differentiated C2C12 myotubes that were treated with aqua-extract of Dioscorea opposita. In addition, the phosphorylations of IRS1 (Insulin receptor substrate 1) and Akt (Protein Kinase B) were also up-regulated in cells. In animal study, the extract was shown to lower plasma triglyceride level, visceral fat, and weight in the STZ/Nicotinamide-induced-diabetic mice fed with high-fat diet. Furthermore, the extract also ameliorated hyperglycemia and improved glucose tolerance in mice. In conclusion, Dioscorea opposita could have beneficial effects on anti-hyperglycemic and anti-obesity.
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