Studies on the bioactivities of essential oils: cytotoxicity, the activity of anti-platelet aggregation, and the improvement on metabolic syndromes

博士 === 中山醫學大學 === 營養學研究所 === 102 === Thirty-eight essential oils (EOs), including 4 products from Taiwanese high-latitude trees, Chamaecyparis formosensis, Taiwania cryptomerioides, Cryptomeria japonica, and Chamaecyparis obtuse, as well as 34 commercial essential oils, were assayed on their cytotox...

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Main Authors: Hsiu-Fang Yen, 顏秀芳
Other Authors: Chin-Kun Wang
Format: Others
Language:zh-TW
Published: 2014
Online Access:http://ndltd.ncl.edu.tw/handle/92615130103350689137
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spelling ndltd-TW-102CSMU55130272015-10-14T00:24:02Z http://ndltd.ncl.edu.tw/handle/92615130103350689137 Studies on the bioactivities of essential oils: cytotoxicity, the activity of anti-platelet aggregation, and the improvement on metabolic syndromes 精油之細胞毒性、抗血小板凝集活性及改善代謝症候群活性 Hsiu-Fang Yen 顏秀芳 博士 中山醫學大學 營養學研究所 102 Thirty-eight essential oils (EOs), including 4 products from Taiwanese high-latitude trees, Chamaecyparis formosensis, Taiwania cryptomerioides, Cryptomeria japonica, and Chamaecyparis obtuse, as well as 34 commercial essential oils, were assayed on their cytotoxicity against 5 cancer cell lines and anti-platelet aggregation function. Two EOs from Juniperus virginiana and Santalum album showed significant cytotoxicity. Moreover, 2 EOs from Melissa officinalis and Piper nigrum exhibited moderate inhibitory effects on an anti-platelet aggregation assay. The cytotoxicity of EOs from J. virginiana and S. album was revealed for the first time. Twenty-nine commercial essential oils (EOs)including three different resources of Melissa officinalis essential oils, were assayed on their glucose consumption and lipid accumulation activities on 3T3-L1 adipocytes. The EOs of M. officinaliswere significantly active in both model assays. Moreover, EOs of Peppermint, Lavender, Bergamot, Cypress, Niaouli Nerolidol, Geranium-Rose and Revensara did not increase glucose consumption, but displayed inhibitory effect on lipid accumulation at 60 μL/L concentration (65~91% of lipid accumulation vs. the control 100 %). Because of the promising activity of M. officinalis EOs, three different products were collected and compared for their chemical profiles and bioactivity. The western blot data suggested that the key factors of the AMPK/ACC pathway can be mediated by M. officinalis EOs. Together with biodata, gas chromatography mass spectrometry (GC-MS) profiles suggested the mixtures of citrals and minor compounds of M. officinalis EOs may play an important role on the effect of anti-diabetes. Chin-Kun Wang 王進崑 2014 學位論文 ; thesis 98 zh-TW
collection NDLTD
language zh-TW
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description 博士 === 中山醫學大學 === 營養學研究所 === 102 === Thirty-eight essential oils (EOs), including 4 products from Taiwanese high-latitude trees, Chamaecyparis formosensis, Taiwania cryptomerioides, Cryptomeria japonica, and Chamaecyparis obtuse, as well as 34 commercial essential oils, were assayed on their cytotoxicity against 5 cancer cell lines and anti-platelet aggregation function. Two EOs from Juniperus virginiana and Santalum album showed significant cytotoxicity. Moreover, 2 EOs from Melissa officinalis and Piper nigrum exhibited moderate inhibitory effects on an anti-platelet aggregation assay. The cytotoxicity of EOs from J. virginiana and S. album was revealed for the first time. Twenty-nine commercial essential oils (EOs)including three different resources of Melissa officinalis essential oils, were assayed on their glucose consumption and lipid accumulation activities on 3T3-L1 adipocytes. The EOs of M. officinaliswere significantly active in both model assays. Moreover, EOs of Peppermint, Lavender, Bergamot, Cypress, Niaouli Nerolidol, Geranium-Rose and Revensara did not increase glucose consumption, but displayed inhibitory effect on lipid accumulation at 60 μL/L concentration (65~91% of lipid accumulation vs. the control 100 %). Because of the promising activity of M. officinalis EOs, three different products were collected and compared for their chemical profiles and bioactivity. The western blot data suggested that the key factors of the AMPK/ACC pathway can be mediated by M. officinalis EOs. Together with biodata, gas chromatography mass spectrometry (GC-MS) profiles suggested the mixtures of citrals and minor compounds of M. officinalis EOs may play an important role on the effect of anti-diabetes.
author2 Chin-Kun Wang
author_facet Chin-Kun Wang
Hsiu-Fang Yen
顏秀芳
author Hsiu-Fang Yen
顏秀芳
spellingShingle Hsiu-Fang Yen
顏秀芳
Studies on the bioactivities of essential oils: cytotoxicity, the activity of anti-platelet aggregation, and the improvement on metabolic syndromes
author_sort Hsiu-Fang Yen
title Studies on the bioactivities of essential oils: cytotoxicity, the activity of anti-platelet aggregation, and the improvement on metabolic syndromes
title_short Studies on the bioactivities of essential oils: cytotoxicity, the activity of anti-platelet aggregation, and the improvement on metabolic syndromes
title_full Studies on the bioactivities of essential oils: cytotoxicity, the activity of anti-platelet aggregation, and the improvement on metabolic syndromes
title_fullStr Studies on the bioactivities of essential oils: cytotoxicity, the activity of anti-platelet aggregation, and the improvement on metabolic syndromes
title_full_unstemmed Studies on the bioactivities of essential oils: cytotoxicity, the activity of anti-platelet aggregation, and the improvement on metabolic syndromes
title_sort studies on the bioactivities of essential oils: cytotoxicity, the activity of anti-platelet aggregation, and the improvement on metabolic syndromes
publishDate 2014
url http://ndltd.ncl.edu.tw/handle/92615130103350689137
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