| Summary: | 博士 === 中山醫學大學 === 營養學研究所 === 102 === Thirty-eight essential oils (EOs), including 4 products from Taiwanese high-latitude trees, Chamaecyparis formosensis, Taiwania cryptomerioides, Cryptomeria japonica, and Chamaecyparis obtuse, as well as 34 commercial essential oils, were assayed on their cytotoxicity against 5 cancer cell lines and anti-platelet aggregation function.
Two EOs from Juniperus virginiana and Santalum album showed significant cytotoxicity. Moreover, 2 EOs from Melissa officinalis and Piper nigrum exhibited moderate inhibitory effects on an anti-platelet aggregation assay. The cytotoxicity of EOs from J. virginiana and S. album was revealed for the first time.
Twenty-nine commercial essential oils (EOs)including three different resources of Melissa officinalis essential oils, were assayed on their glucose consumption and lipid accumulation activities on 3T3-L1 adipocytes. The EOs of M. officinaliswere significantly active in both model assays. Moreover, EOs of Peppermint, Lavender, Bergamot, Cypress, Niaouli Nerolidol, Geranium-Rose and Revensara did not increase glucose consumption, but displayed inhibitory effect on lipid accumulation at 60 μL/L concentration (65~91% of lipid accumulation vs. the control 100 %). Because of the promising activity of M. officinalis EOs, three different products were collected and compared for their chemical profiles and bioactivity. The western blot data suggested that the key factors of the AMPK/ACC pathway can be mediated by M. officinalis EOs. Together with biodata, gas chromatography mass spectrometry (GC-MS) profiles suggested the mixtures of citrals and minor compounds of M. officinalis EOs may play an important role on the effect of anti-diabetes.
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