Air Pollution and Alzheimer’s disease: A Population-Based Prospective Cohort Study in Taiwan

• Main Authors: Shih-Wei Weng, 翁詩瑋
• Other Authors: Bing-Fang Hwang
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/39647986194008773757

碩士 === 中國醫藥大學 === 職業安全與衛生學系碩士班 === 102 === Abstracts Background: There is evidence that air pollution may increase the risk of Alzheimer’s disease in animals, but limited epidemiological studies concerning the role of ambient air pollution in the relation to Alzheimer’s disease. The aim of this study will assess the relation between ambient air pollution and the risk of Alzheimer’s disease. Methods: We conducted a population-based 10-year prospective cohort study in Taiwan. The outcome of interest was development of Alzheimer’s disease during the study period from 2000 through 2010. The air pollutant measurements from 72 EPA monitoring stations are integrated into yearly point data and interpolated to pollutant surfaces using inverse distance weighting (IDW) method since 1994. The exposure assessment was based on residential zip-code during the study period. The effect estimates were presented as hazard ratios per interquartile range (IQR) for the air pollutant. Results: Alzheimer’s disease have four groups, this proposal show you about one, Alzheimer''s disease. A total of 1764 subjects developed Alzheimer’s disease during the study period. In the Cox proportional hazard model adjusting for confounders, the risk of Alzheimer’s disease was increased in relation to NO2 (adjusted HR=1.16, 95% CI: 1.09,1.24) and SO2 exposure (adjusted HR=1.08, 95% CI: 1.05, 1.12). Conclusion: The study provides evidence that exposure to ambient air pollutants such as NO2 and SO2 may increase the risk of Alzheimer’s disease.