| Summary: | 碩士 === 中國醫藥大學 === 藥物化學研究所碩士班 === 102 === An effective 1,3-dipolar cycloaddition was successfully developed for synthesis 5-amino-1,2,4-triazoles by reacting hydrazonoyl hydrochlorides (nitrilimines) with carbodiimides in the presence of triethylamine as a base catalyst. Carbodiimides can be adapted to the newly developed reaction condition, except for diphenyl carbodiimide. All of 5-Amino-1,2,4-triazoles were evaluated against a panel of human cancer cell lines in vitro, including lung carcinoma (NCI-H226), nasopharyngeal (NPC-TW01), and T-cell leukemia (Jurkat) cells. Based on the IC50, result, most of them provided the poor inhibitory potency.
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